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Hol Hom Hor Hos Hou How

Howell–Jolly body

1. Histopathological findings of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow erythrocytes normally expel their nuclei, but in some cases a small portion of DNA remains. (wikipedia.org)

2. Spherical or ovoid nuclear fragments found in newly differentiated erythrocytes. Red Blood cells with these bodies appear in greater numbers after a splenectomy. (www.bloodbook.com)

3. Spherical or ovoid eccentrically located granules, approximately 1 um in diameter, occasionally observed in the stroma of circulating erythrocytes, especially in stained preparations (as compared with wet unstained films); probably represent nuclear remnants, inasmuch as they can be stained with dyes that are rather specific for chromatin; the significance of the body’s is not exactly known; they occur most frequently after splenectomy or in megaloblastic or severe haemolytic anaemia. (biology-online.org)

4. Small round remnants of nuclear DNA inside cell; present in sickle cell anaemia, haemolytic or megaloblastic anaemias, and may be seen after a splenectomy. (labtestsonline.org.uk)

Syn: Jolly bodies

Name origin: It is named for William Henry Howell and Justin Marie Jolly.