episode47

047 Action Potentials and Contraction in Cardiac Muscle Cells

Leslie explains how action potentials are generated by the cardiac cells of the heart and how the release of calcium can generate heart contraction.

Watch to learn more.

Enjoy!

Transcript of Today’s Episode

Hello and welcome to another episode of Interactive-Biology TV where were making Biology fun. My name is Leslie Samuel and in this episode, Episode 47, I’m going to be talking about action potentials and contraction in cardiac muscle cells. So, let’s get right into it.

I’m looking at the heart. We’ve looked at a number of things related to the heart. In the previous episode, we spoke about the SA node, which is what we see here, number one and, we spoke about the AV node, which is this part here, number two, and we spoke about these Purkinje fibers. I’m just going to write PF for now. So, this is the AV node, the SA node and the Purkinje fibers. You can go back to the previous episode to learn more about those, in case you’re not sure what they do; in case you’re not sure how they function.

There are a number of things that I want you to know here. We said that the SA node functions as the pacemaker. There’s an important feature about the heart muscle cells that you need to be aware of. That is the fact that these cells are all electrically connected. So, all of the muscle cells in the ventricle are electrically connected, all of the muscle cells in the atria are also electrically connected.

What that means is that if one of the cells in the ventricle gets stimulated, that signal is going to travel to all of the other cells in the ventricle. Not only that, but, if the SA node starts a signal, that signal is going to spread. This is why we get the heart contracting in response to the signal that’s generated by the SA node. Then, when it reaches the AV node and it spreads via the Purkinje fibers, that signal spreads to all of the muscle cells in the ventricles, causing the ventricles to contract.

There are some other important details that you need to know. When the signal is generated in the SA node and it spreads to the atria, the conduction velocity is one meter per second (1 m/s). So, the signal spreads at a speed of 1 m/s here. At the AV node, it slows down to where it’s somewhere around 0.04m/s. Then, in the Purkinje fibers, it speeds up significantly, and we get a conduction velocity of 5 m/s.

So, what this means is that we have a signal that starts here and spreads throughout the atria relatively quickly at 1 m/s but then, it slows down at the atrioventricular node to 0.04 m/s. So, there’s a delay here, and then, after it passes the atrioventricular node, that signal spreads rapidly to the ventricles. Now, why do we want this? As we mentioned before, the blood first goes to the atria and then, the atria contracts, sending the blood from the atria to the ventricles.

You don’t want the atria and the ventricles contracting at the same time. That would cause problems. You want the ventricles to get filled with the blood from the atria first and then, you want the ventricles to contract sending all that blood to the rest of the body and to the lungs. So, that’s how that works and that is why it’s good that we have this slowing down at the atrioventricular node.

Now that we know that and now that we understand that the muscle cells are all connected electrically, let’s move on and look at what happens inside the muscle cells.

We have a stimulus that comes from the AV node or the SA node and that spreads to the muscle cells. In response to that, what’s going to happen is that the membrane potential of the cardiac muscle cells is all of a sudden going to depolarize very quickly. So, we have that initial depolarization. When the muscle cells depolarize, as with skeletal muscles, we’re going to have calcium being released from the sarcoplasmic reticulum. For a refresher of how that works, you can go back to Episode 42 where I talked about calcium release and how that causes muscle contraction.

Once the calcium is released from the sarcoplasmic reticulum, that’s going to prevent the repolarization that normally happens rather quickly. With a normal neuron, the action potential lasts less than a millisecond. However, in cardiac muscle cells, we have calcium that’s being released that slows down the repolarization process and we get a phase that’s referred to as the ‘plateau.’ The membrane potential does not repolarize as quickly. Then, at a certain point, calcium gets pumped back into the sarcoplasmic reticulum, potassium also leaves as usual, and we get the repolarization of the cardiac muscle cells.

As you can see, the time scale that we have here shows that this action potential can last as much as 300 milliseconds as opposed to the one millisecond or less than one millisecond that we get with a neuron. That’s because of the calcium released. That’s because of this plateau phase.

Let’s see what that does for muscle contraction. Yes, we’re going to have a depolarization but then, we’re going to have the calcium released and that is going to cause the muscle cells to contract just like I showed in Episode 42. Once again, you can always go back at Episode 42 to revisit that concept.

This is what we’re going to do. I’m going to plot the tension in the cardiac muscle cells. So, we’re looking at the cardiac muscle and here, nothing is happening. But, as soon as calcium starts being released, that’s going to cause the muscle cells to contract. This is what’s going to happen. This is the tension and then, once calcium starts being pumped back into the sarcoplasmic reticulum, the muscle cell is going to relax and go back to its resting state.

So, we have the action potential lasting significantly longer than we’ve seen before, because of the calcium that’s released from the sarcoplasmic reticulum and that calcium then causes the muscle cells to contract and we get this tension in the muscle cells.

As the calcium gets pumped back into the sarcoplasmic reticulum and the potassium ions leave, that is going to cause the muscle cells to relax and go back to its original state.

And that’s pretty much it. The action potential causes calcium release. Calcium release causes muscle contraction.

That’s all I’m going to cover in this video. As usual, you can head back to the website at Interactive-Biology.com for more Biology videos and for more resources that we’re adding there on a regular basis. So, stay tuned. This is Leslie Samuel. That’s it for this video and I’ll see you on the next one.

138 comments
Elizabeth
Elizabeth

Thank you so much!! I seriously wish that you were my professor. Just a question though,  but what is the tension for? What does the second one that you graphed mean? 

imelda flores
imelda flores

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Susan
Susan

This was super helpful! Thank you :D

brumified
brumified

Moreso* Also they extend directly from the AV node

brumified
brumified

@anas lahrichi The bundle of His is a cluster if specialised conduction myocardiocytes, they transmit that electrical energy from the AV node to the Purkenje Fibres; so they function to transmit charge Moreno than concentrate it as in the AV node cardiomyocytes.

adam Kemp
adam Kemp

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Justin Forester
Justin Forester

Yes. AP ends once it reaches the resting potential again.

Mobimobipopo
Mobimobipopo

Does The action potential includes Depolarisation phase and the plateau?

anas lahrichi
anas lahrichi

Where is the bundle of his located ? Has it the same role ?

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Ayesha Thandeniya
Ayesha Thandeniya

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iris prince
iris prince

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UtubeDeShayna
UtubeDeShayna

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youn9024
youn9024

Bundle of His = AV bundle :)

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ldyluv6988
ldyluv6988

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Priscilla Alameda
Priscilla Alameda

Will appreciate it if the Bundle of His was also mentioned...Thanks! =) The videos are REALLY helpful. Good job!

sabah1242
sabah1242

the videos are really good for revision! thankyou! can i just ask tho, in smooth/skeletal muscles, calcium is released aswell from the sarcoplasmic reticulum so why doesnt that result in a plateau phase..? is it to do with the timings, because action potentials are time dependent also?

Claymobileation
Claymobileation

I just watched this video to study for a my test today. Thanks.

digi aquino
digi aquino

love this! helps me prepare for my exam

mirrorreflex
mirrorreflex

Also if the heart did have tetanic contraction it would fatigue, which we do not want as our heart is needed all the time.

mirrorreflex
mirrorreflex

Also if the heart did have tetanic contraction it would fatigue, which we do not want as our heart is needed all the time.

Scoffstache
Scoffstache

gives time for ventricular filling and prevents tetanic contraction